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All of Us Resource Guide

About the All of Us Research Program

The National Institutes of Health’s (NIH’s) All of Us Research Program is working to improve health care through research and build one of the largest biomedical data resources of its kind with health data from a diverse group of participants across the United States. All of Us is committed to recruiting a diverse participant pool that includes members of groups that have been left out of research in the past.

Data Sources Include:

The diverse database, which is a part of the Precision Medicine Initiative, is intended to inform studies on a multitude of health conditions.

All of Us is part of a new era in which researchers, health care providers, technology experts, community partners, and the public work together to develop individualized health care.

About the All of Us Research Hub

The All of Us Research Hub stores health data from a diverse group of participants from across the United States. Its goal is to advance precision medicine research and fuel new insights into human health. There are three tiers of data access: Public (no login required); Registered (login required); and Controlled (additional approval required). Access to the higher tier levels is reserved for approved researchers, faculty, and staff.

The Public Tier

Everyone is able to access data using Data Snapshots and the Data Browser. This tier contains only aggregate data with identifiers removed Much information can be accessed at this level and is available regardless of registration status. Additionally, users have access to the Research Projects Directory and All of Us Publications.

Learn more about using the Data Browser.

Research Projects Directory

Users are able to explore a wide range of biomedical and health research. The searchable directory provides information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used.

Publications

The All of Us library provides access to scientific publications that have used All of Us data in their research.

The Registered Tier

Available to only approved researchers on the Researcher Workbench, this tier contains individual level data from EHRs, wearables, and surveys, as well as physical measurements taken at the time of participant enrollment.

The Controlled Tier

In addition to the data in the Registered Tier, the Controlled Tier dataset contains genomic data in the form of whole genome sequencing (WGS) and genotyping arrays, previously suppressed demographic data fields from EHRs and surveys, and unshifted dates of events.

The Researcher Workbench

The Researcher Workbench is a cloud-based platform with powerful tools that support data analysis and collaboration. These tools include:

Workspaces: Access, store, and analyze data for specific research projects. 

Notebooks:  Perform high-powered queries and analysis using R or Python

Dataset Builder: Search and save collections of health information about cohorts

Cohort Builder:  Create, review, and annotate groups of participant data 

Within the Researcher workbench, integrated help and educational resources are provided through the Workbench User Support Hub.

Learn more about the Researcher Workbench

Register for Access

Access to the All of Us Researcher Workbench is available only to registered researchers with an institutional Data Use and Registration Agreement (DURA). 

Initial access to the Researcher Workbench will not be immediate.  There are several steps needed before access is granted, and you should expect a wait of at least a week or more to receive full access.

Preview of the registration process

Registering for access to the Researcher Workbench can be accomplished through five steps.

1.    Create a Researcher Workbench Account

Complete your researcher profile, sign the Terms of Service, and agree to the Privacy Policy. Be sure to save your credentials.  You will be creating a Google email account (@researchallofus.org).

2.    Verify your Identity using login.gov

Login.gov verifies your identity for the agency. By submitting personal identifiable information (PII), such as your photo ID, you can verify that you are you and not someone pretending to be you. This service only confirms that you are you and does not make any determination on eligibility for agency services.

 Additional instructions on completing this step

3.    Login to Researcher Workbench

(using the account you created @researchallofus.org).

4.    Complete the Responsible Conduct of Research Training

This mandatory training, provides education on conducting responsible and ethical research with data from All of Us participants.

5.    Sign the Data User Code of Conduct.

The Data User Code of Conduct is an agreement that outlines the program’s expectations for researchers.

Preview of the Data User Code of Conduct

All of Us Support Tools and Resources

User Support Hub

Searchable repository for articles and videos answering questions about usage of the Researcher Workbench or explore researcher workbench resources

All of Us Support Desk

The All of Us Support Desk will assist in resolving technical issues and answer questions. They can be contacted at support@researchallofus.org.

All of Us Live Event Calendar

Weekly office hours are available for registered users.

Selected Resources

Coding Resources

R

Python

Further Reading

All of Us Research Hub

National Institute of Health All of Us Research Program

Support Hub Video Directory

All of Us Research Program YouTube Channel

References

Data Access Tiers. (2023). Retrieved from All of Us Research Hub: https://www.researchallofus.org/data-tools/data-access

Data Sources. (2023). Retrieved from All of Us Research Hub: https://www.researchallofus.org/data-tools/data-sources

Health, N. I. (2021). All of Us Research Program Overview . Retrieved from National Institutes of Health All of Us Research Program: https://allofus.nih.gov/about/program-overview

Opportunities for Researchers. (2023). Retrieved from National Institutes of Health All of Us Research Program: https://allofus.nih.gov/get-involved/opportunities-researchers

Register to Be an All of Us Researcher. (2023). Retrieved from All of Us Research Hub: https://researchallofus.org/register/

Researcher Workbench. (2023). Retrieved from All of Us Research Hub: https://www.researchallofus.org/data-tools/workbench/?_gl=1*qhqewc*_ga*MjAyNTgwMTI2NC4xNjcxNTcxNjUw*_ga_7MXT5FNNB6*MTY4ODEzNTA1OC4zMS4xLjE2ODgxMzUwNzAuMC4wLjA.

Welcome to the All of Us Research Hub. (2023). Retrieved from All of Us Research Hub: https://researchallofus.org/

What is Login.gov? (n.d.). Retrieved from Login.gov: https://login.gov/what-is-login/

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